2 edition of role of cadmium ions in hypertension. found in the catalog.
role of cadmium ions in hypertension.
Written in English
M.Sc. dissertation. Typescript.
|The Physical Object|
|Number of Pages||43|
Cadmium is a toxic and carcinogenic metal widely distributed in the environment [Agency for Toxic Substances and Disease Registry (ATSDR) ; International Agency for Research on Cancer (IARC) ; Nordberg et al. ).In the general population, the primary sources of cadmium exposure are cigarette smoke, food intake (shellfish, offal, certain . Calcium ions (Ca 2+) contribute to the physiology and biochemistry of organisms play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in enzymes require calcium ions as a cofactor, including several of the .
Natural waters are mostly polluted by heavy metal ions caused by industrial wastage. Due to their toxic effects metal ions pose a serious threat to living organisms (Khan et al. ; Singh et al. ; Zhao et al. a, b) and the environment in terms of growth, yield and quality of crops and plants (Singh & Agrawal ; Ok et al. ).Mercury, cadmium, arsenic, chromium and . sion and in the rat model of spontaneous hypertension are of potential scientific and clinical interest. This review is an attempt to critically analyze the pertinent available data with the following objectives in mind: 1. To present the evidence for and against the role of calcium deficiency in genetic hypertension 2.
Sodium ions (Na +) are necessary in small amounts for some types of plants, but sodium as a nutrient is more generally needed in larger amounts by animals, due to their use of it for generation of nerve impulses and for maintenance of electrolyte balance and fluid animals, sodium ions are necessary for the aforementioned functions and for heart activity . Cadmium and hypertension D. M. Templeton and M. G. Cherian Department of Pathology, Umversity of Western Ontario, London, Ontario, N6A 5C1, Canada The issue of an etiological role of cadmium in human essential hypertension has been considered for the last two decades. The question is far from settled and conflicting.
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Measures is needed for further definition of the role of cadmium in "idiopathic" human hypertension. Cadmium, an environmental trace metal, is a common pollutant of air, water, and food consumed by humans.
Cadmium has been implicated as a pos-sible factor in hypertension and arte-riosclerotic heart disease (Schroeder1). Cadmium is associated with hypertension, but less so with CHD, CVD, and CVA. Renal cadmium reduces CYP4A11 and PPARs, which may be related to hypertension, sodium retention, glucose intolerance, dyslipidemia, and zinc deficiency.
Dietary calcium may mitigate some of the toxicity of by: 1. The role of calcium in clinical hypertension can be best understood by a hierarchal model in which the blood pressure effects of a dietary signal depend on alterations of hormonal systems specific for that signal.
These alterations mediate both the cellular recognition of these signals as well as the resultant clinical responses to by: This book illustrates remarkable roles of metal ions in the neuropathophysiology of stroke, which is a major cause of death and disability worldwide. Metal ions have unique chemical properties that al The Role of Mercury and Cadmium in Cardiovascular Disease, Hypertension, and Stroke.
Mark C. Houston Pages Back Matter. Pages. Cadmium, a toxic heavy metal, has been incriminated in the etiology of essential hypertension. Zinc, an essential micronutrient necessary for growth, competes with cadmium for binding sites in biochemical processes; zinc deficiency states (i.e.
pregnancy and low protein diet) might expose an individual to increased risk of cadmium by: A significant age-related increase in selenium and decrease in copper ions was observed for the first time in the lens tissue, where cadmium ion levels.
The adsorption of cadmium ions onto bone char has been studied using a batch adsorber. The experimental data was analyzed using four sorption kinetic models-the pseudo-first order, the Ritchie second order, the modified second order and the Elovich equations-to determine the best-fit equation for the sorption of metal ions onto bone char.
T he role of cadmium in induct ion of. atherosclerosis in rabbits. Indian heart journal, 44 (3), Cadmium ion uptake by the adsorbents increased with increase in pH fromwith HK.
About this Book Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject.
Written by 41 cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered. Blood Cadmium. Elevated blood cadmium levels confirm recent acute exposure, (Jarup ; ATSDR ) but do not correlate with body burden or clinical outcome, and should not be used to determine the need for treatment.
The 95% confidence limit for blood cadmium levels in the United States for healthy nonexposed, nonsmokers is micrograms. One identifiable factor that plays a central role in Cd-induced hepatotoxicity (acute), nephrotoxicity (chronic), and cardiovascular complications in living organisms which has been the focus of much research is the excessive generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS).
Metal ions played critical role in regulation of hypertension (HT) or blood pressure (BP). The physiological roles of metals commonly present in the diet in the etiology of HT need to be reviewed as recent survey on the metal status in the various vegetable and meat food stuffs commonly consumed by living population in India revealed an imbalance in its level.
Hypertension remains the leading cause of cardiovascular disease (CVD), affecting approximately 1 billion individuals worldwide. 1 Although more than 72 million Americans, or nearly 1 in 3 adults, are estimated to have hypertension, blood pressure (BP) control is achieved in only 35% 2; recent surveys estimate that a higher percentage of patients.
A simple and label-free colorimetric method for cadmium ions (Cd2+) detection using unmodified gold nanoparticles (AuNPs) is reported. The unmodified AuNPs easily aggregate in a high concentration of NaCl solution, but the presence of glutathione (GSH) can prevent the salt-induced aggregation of AuNPs.
When Cd2+ is added to the stable mixture of AuNPs, GSH. Further evidence that Cadmium has a role to play in hypertension was revealed in the March Strong Heart Study published in the Journal of Human Hypertension ( Mar; 31 (3): –). The background to the study is that the American Indians are thought to have above national average in Cadmium exposure.
Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine. Oct [PubMed PMID: ]  Houston MC, The role of mercury and cadmium heavy metals in vascular disease, hypertension.
Spherical protein cages with highly symmetrical structures provide unique environments for the conjugation of metal ions and metal nanoparticles. Ferritin has been widely studied as a template for the coordination of metal ions and metal nanoparticles in fundamental research and applications.
However, it rem The central role of the d-block metals in the periodic table. Aoshima, K, Kasuya, M: Environmental exposure to cadmium and effects on human health. Part 3. The results of blood examinations and blood pressure in inhabitants of the cadmium-polluted Jinzu River basin in Toyama Prefecture [in Japanese, with English abstract] Jpn J Hyg– Amonginhabitants of a cadmium-polluted Toyama area, the authors.
Cadmium is a heavy metal that is extremely harmful for environmental and human health. 1,2 Once it enters the human body, it will accumulate with a half-life of 10–30 years. 3 Cadmium can cause serious health problems, including hypertension, 4 skeletal lesions, 5 and immune and nervous system damage.
6,7 In addition, it can also cause teratogenic effects. Chronic cadmium exposure has been reported to cause mild anemia, anosmia, yellowing of teeth, and, occasionally, liver damage. There is no conclusive evidence that cadmium alone causes hypertension.
However, cadmium-induced renal dysfunction can eventually manifest in hypertension. Female rats on a cadmium-free diet exhibited fluctuating systolic hypertension when given cadmium in drinking water at subtoxic levels (5 ppm) from the time of weaning for – days.
Relatively small accumulations of cadmium in kidney and liver were present, and hypertension was the only sign of toxicity.Cadmium is a chemical element with the symbol Cd and atomic number This soft, silvery-white metal is chemically similar to the two other stable metals in gr zinc and zinc, it demonstrates oxidation state +2 in most of its compounds, and like mercury, it has a lower melting point than the transition metals in groups 3 through and residual concentration of cadmium ions.
Standard solutions for calibration were prepared using a cadmium standard solution of mg/L of cadmium nitrate in M nitric acid. Measurements were made in triplicate and those results in which the standard deviations were found beyond 95% limit were not accepted.